Gastric upset

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Cuillin
Posts: 15
Joined: Wed Sep 07, 2011 2:39 pm
Location: Scotland

Gastric upset

Post by Cuillin » Wed Sep 07, 2011 4:32 pm

Hello from Bonnie Scotland! :)
Our pet Beagle, now aged 9, was diagnosed with epilepsy when he was 2. His seizures have been reasonably controlled by a combination of Potassium Bromide and Phenobarbitone. A couple of months ago his Pot Brom liquid solution was discontinued so he was commenced on tablet form instead. Since then he has developed symptoms of gastritis - early am vomiting initially but over the past week he has vomited copiously (rendering him unable to digest his epilespy meds, so frequent seizures), lost his appetite (unheard of in a Beagle!) and experiencing random abdo pain. Has anyone any experience of this kind of side-effect from Pot Brom? If so, how was it dealt with?
Having an epileptic dog seems a lonely path at times - but what he gives back in companionship, fun, affection and sheer stubborn, self-willed, Beagle personality is worth more than money can buy - and I hate the frustration of not being able to restore his quality of life. :(

Jim1155
Posts: 6
Joined: Mon Oct 04, 2010 6:47 pm

Re: Gastric upset

Post by Jim1155 » Wed Sep 07, 2011 7:31 pm

We have a english springer spaniel that we are giving Phenobarbital and the liquid Potassium Bromide, and are still able to get it. I am wondering why you can't. I have heard that the pill is harder for them to digest as you have found out.

Jim

Cuillin
Posts: 15
Joined: Wed Sep 07, 2011 2:39 pm
Location: Scotland

Re: Gastric upset

Post by Cuillin » Thu Sep 08, 2011 10:04 am

Jim, we were told we could no longer be supplied with it because the formulation wasn't registered for canine use (Very odd because it was originally prescribed from the Glasgow Vet School neurology dept) and Libromide tablets are. He is now on Epilease which is classified as a food supplement rather than a drug.

He's actually relapsed again today and is refusing all food (and meds of course) He's had anti-emetic, analgesic injection, antibiotic and Zantac syrup - I'm hoping he'll wake up and take his epilepsy meds anytime soon.

Cuillin
Posts: 15
Joined: Wed Sep 07, 2011 2:39 pm
Location: Scotland

Re: Gastric upset

Post by Cuillin » Thu Sep 08, 2011 12:37 pm

Jim, further to the above - because Libromide is the only officially recognised drug for use with phenobarb, all new referalls must be prescribed it as an adjunct therapy. A case could have been made for Hound to have been allowed to remain on the syrup but unfortunately the manufacturer decided to stop producing it. :(

As far as I can work out, because Libromide has the official licence they can now properly research the efficacy and effects of the treatment whereas Potassium Bromide as a food supplement was freely available and its' use unregulated.

Jim1155
Posts: 6
Joined: Mon Oct 04, 2010 6:47 pm

Re: Gastric upset

Post by Jim1155 » Fri Sep 09, 2011 9:22 pm

Bonnie,
I hope that doesn't happen here in the states. We have found that a combination of Phenobarbital and Potassium Bromide is what works best for Olivia. We have gone from a monthly occurance to up to 7 months now since her last one, and that one was a short one with little post ictal effects.

Jim

Cuillin
Posts: 15
Joined: Wed Sep 07, 2011 2:39 pm
Location: Scotland

Re: Gastric upset

Post by Cuillin » Sat Sep 10, 2011 6:25 am

That's great news about Olivia's seizures - hope she continues to maintain current status with current meds.

Clare (sorry for the confusion re names, I was just trying to indicate that I was posting from Bonnie Scotland so my posts are likely to be made at different times to those in the US.)

Carolyn
Posts: 440
Joined: Thu Feb 16, 2006 12:08 pm
Location: Long Island, NY

Re: Gastric upset

Post by Carolyn » Tue Sep 13, 2011 8:54 am

Hi Cuillin maybe you could question higher authorities about the liquid potassium bromide, since it is so common. My new vet was suprised I use the liquid form but I have for over 5 years, she uses pill form. I recently changed vets and they told me they could not write a prescription for a 90 day supply of phenobarbitol because it was a controlled substance. So once again I had to have them call my states narcotics bureau for the correct codes and today I pick up my 90 day prescription.
I am not aware of liquid potassum bromide being manufactured, it is compounded. You can't get it everywhere you have to go to a compounding pharmacy. They did change the formular about a year ago here, I was told there were so many dogs on it they wanted a set formula for everyone. Walmart told me if I could get them the ingedients they would compound it, I didn't know what to say to that. So I still go to my local CVS drugstore for the kbr. I have learned over the years sometimes I don't take "No" for an answer, at least not until I have done all I can, specially when it comes to Kiya.
Carolyn
Kiya 11yr Shiloh Shepherd
PB 60mg am 90mg pm, 1teas kbr 1200mg, turmeric paste
1000mg milkthistle bid
First seizure 11/27/05
Last seizure 5/21/15

Cuillin
Posts: 15
Joined: Wed Sep 07, 2011 2:39 pm
Location: Scotland

Re: Gastric upset

Post by Cuillin » Tue Sep 13, 2011 3:33 pm

Thanks Carolyn, unfortunately the availability of these formulas is different in the UK. The manufacturer of Cuillin's liquid potassium bromide has ceased production.

Sadly, Cuillin failed to respond to anyof the treatments our vet instigated and he was admitted to hospital in Edinburgh this am for major investigative surgery - it does not seem as straightforward as a reaction to his medications after all. :(

But he's a fighter so I'm still hopeful of a happy outcome...

Clare

Carolyn
Posts: 440
Joined: Thu Feb 16, 2006 12:08 pm
Location: Long Island, NY

Re: Gastric upset

Post by Carolyn » Thu Sep 15, 2011 10:32 am

Im so sorry Cuillin's having such a hard time, I hope he starts to feel better. It's so hard to see them suffering but you know your doing everything you can and that is all you can do. Good luck.
Carolyn
Kiya 11yr Shiloh Shepherd
PB 60mg am 90mg pm, 1teas kbr 1200mg, turmeric paste
1000mg milkthistle bid
First seizure 11/27/05
Last seizure 5/21/15

Mandypop
Posts: 238
Joined: Wed Oct 25, 2006 9:29 am
Location: London, UK

Re: Gastric upset

Post by Mandypop » Tue Sep 20, 2011 9:16 am

Hi Clare

So sorry to hear that Cuillin's having problems at the moment.

I'm also in the UK and had to switch from the potassium bromide syrup to tablets. I think I read that Vetoquinol who manufactured the syrup did not apply for a licence for use in dogs so the product got withdrawn; and as my dog was on just 1.1ml of the syrup and the smallest tablets are 325mg it took a bit of adjustment.

The tablets had a bit of a bad effect on my dog, upset tummy and also ataxia, but she has now settled down and is doing okay apart from the tablets seem to make her even more hungrier than ever!

Do hope it's good news for Cuillin.

Mandy
Poppy - 9 year old whippet/greyhound (20 kg)

First seizure- 17th Oct 2006
Last seizure - 17th Nov 2009

90mg Pb twice daily
320mg KBr daily

Cuillin
Posts: 15
Joined: Wed Sep 07, 2011 2:39 pm
Location: Scotland

Re: Gastric upset

Post by Cuillin » Tue Sep 20, 2011 10:31 am

Hi Mandy,

Thanks so much for your good wishes. Unfortunately Cuillin got admitted back to hospital this afternoon after less than 48 hours at home. :(

He was commenced on Keppra syrup last week and had his phenobarb and KBr reduced but has gone from having overnight seizures to being severley ataxic - but, joy of joy, he regained his appetite so he is moving in the right direction!

Hope your dog is now thriving on her new regime.

Clare

Mandypop
Posts: 238
Joined: Wed Oct 25, 2006 9:29 am
Location: London, UK

Re: Gastric upset

Post by Mandypop » Thu Sep 22, 2011 4:07 am

Hi Clare

so sorry that Cuillin got re-admitted, lots of vibes that he will make a good recovery.

I am very luck that Poppy has been easy to 'control' seizure wise, our only hiccup was when she was on anti imflammatories, and we had break through seizures, upping pb didn't work, hence the addition of KBr. Even on this combination, we have been very lucky and I am thankful for that. There are many dogs who have such a hard time even on meds.

Mandy
Poppy - 9 year old whippet/greyhound (20 kg)

First seizure- 17th Oct 2006
Last seizure - 17th Nov 2009

90mg Pb twice daily
320mg KBr daily

Cuillin
Posts: 15
Joined: Wed Sep 07, 2011 2:39 pm
Location: Scotland

Re: Gastric upset

Post by Cuillin » Thu Sep 22, 2011 8:09 am

Hi Mandy,

Thanks for those positive vibes. Cuillin is still in hospital but making good progress and things are looking more postive than they were earlier in the week.

Best wishes to yourself and Poppy.

Clare

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