Need Help

Share your story, questions, concerns.

Moderators: Box40Rin, Liz Hansen

rougehs1
Posts: 8
Joined: Mon Feb 07, 2011 10:15 am

Need Help

Post by rougehs1 » Mon Feb 07, 2011 10:31 am

Hi, I am new to the form. I have a 6 yr old GSD who starting having seizures in Aug of 2010. She is currently on both the Pheno and Potas Bromide. None of which have stopped her from having seizures. She has 3 - 5 at the same time of every month and then nothing until the next month whereshe will have 1 (sometimes 2) over 3 - 5 days. It's been the same pattern since it started (6 months). They started her on PB and kept increasing the levels until they got to high. At that point they dropped the PB and added the KBR. I have recently changed her to a part of a RAW diet and took out any treat that contains any wheat.

Her back legs are SO WEAK that she can barely stand up but i am not sure which of the drugs is causing the issue. Both of them are within the appropriate levels but she is continuing to have seizures. I can't increase the drugs as seeing her stumble around doesn't seem fair.

Any ideas of which would be the better drug to reduce? Which would cause the weekness or is it a combo of both that makes it even worse.

PLease help :(

MK's mom
Posts: 1708
Joined: Wed Mar 01, 2006 9:48 am
Location: Michigan

Re: Need Help

Post by MK's mom » Mon Feb 07, 2011 10:47 am

Are you seeing any correlation between the episodes and say, flea treatment or heartworm treatment? what about weed killers outside or anything chemical such as this?

Vivian
Nathan
3.5 yo Irish Setter boy
First seizure 7/26/2013
Last seizure 3/24/2014
__________________________________
MK
5 yo Irish Setter boy
First seizure 1/25/06
Last seizure 9/4/2009

Aug 17, 2004- Sept. 22, 2009
May the shamrocks fall softly sweetpea

rougehs1
Posts: 8
Joined: Mon Feb 07, 2011 10:15 am

Re: Need Help

Post by rougehs1 » Mon Feb 07, 2011 10:57 am

All of her Blood work comes back normal. I live in Canada so right now there is no weed killer as we are covered in snow. She is not on any heartworm or flea treatments. All the seizures/episodes are exactly the same. It's so on schedule adn i am not sure what that means. No triggers.

MK's mom
Posts: 1708
Joined: Wed Mar 01, 2006 9:48 am
Location: Michigan

Re: Need Help

Post by MK's mom » Mon Feb 07, 2011 11:09 am

That is strange! Because it's on time one would think there IS a trigger. What about hormones fluctuating? Is she spayed?
Nathan
3.5 yo Irish Setter boy
First seizure 7/26/2013
Last seizure 3/24/2014
__________________________________
MK
5 yo Irish Setter boy
First seizure 1/25/06
Last seizure 9/4/2009

Aug 17, 2004- Sept. 22, 2009
May the shamrocks fall softly sweetpea

rougehs1
Posts: 8
Joined: Mon Feb 07, 2011 10:15 am

Re: Need Help

Post by rougehs1 » Mon Feb 07, 2011 11:17 am

yes, she is spayed. The only thing we have not tested for was things like Brain Tumor. How would you tell if her hormones are fluctuating?

MK's mom
Posts: 1708
Joined: Wed Mar 01, 2006 9:48 am
Location: Michigan

Re: Need Help

Post by MK's mom » Mon Feb 07, 2011 11:20 am

I have no idea about checking hormones, perhaps your vet knows if there's a way. Have you had a full thyroid panel done?
Nathan
3.5 yo Irish Setter boy
First seizure 7/26/2013
Last seizure 3/24/2014
__________________________________
MK
5 yo Irish Setter boy
First seizure 1/25/06
Last seizure 9/4/2009

Aug 17, 2004- Sept. 22, 2009
May the shamrocks fall softly sweetpea

rougehs1
Posts: 8
Joined: Mon Feb 07, 2011 10:15 am

Re: Need Help

Post by rougehs1 » Mon Feb 07, 2011 11:25 am

no, have not done the thyroid. I did mention it but he thinks that there would be other issues that would point to the thyroid. I have no idea what to do or think anymore. one other thing i have been reading alot about is adding a vitamin B complex.

MK's mom
Posts: 1708
Joined: Wed Mar 01, 2006 9:48 am
Location: Michigan

Re: Need Help

Post by MK's mom » Mon Feb 07, 2011 12:20 pm

A full thyroid panel is one of the first things a vet checks. The two best places in the US (I'm not familiar with Canada) is Michigan State University or Jean Dodds in CA, but it must be a FULL thyroid panel.

Do you trust your vet with this?
Nathan
3.5 yo Irish Setter boy
First seizure 7/26/2013
Last seizure 3/24/2014
__________________________________
MK
5 yo Irish Setter boy
First seizure 1/25/06
Last seizure 9/4/2009

Aug 17, 2004- Sept. 22, 2009
May the shamrocks fall softly sweetpea

rougehs1
Posts: 8
Joined: Mon Feb 07, 2011 10:15 am

Re: Need Help

Post by rougehs1 » Mon Feb 07, 2011 3:19 pm

ya, I think I do. i have never had a reason not to but then again I have never had a situation like this.

Apache
Posts: 256
Joined: Mon Mar 08, 2010 7:50 pm

Re: Need Help

Post by Apache » Mon Feb 07, 2011 9:08 pm

I do know that Phenobarbital will cause hind-end weakness. However, after a bit of time, they usually get accustomed to the medication and their back leg weakness becomes less apparent.

Curious, how long ago was it when they found out that her Pheno levels were too high? The reason I'm asking, is because with our guy, (as an example, tonight) he's been practically dragging his rear legs. He's also quite wobbly, too. He just had a double dose of Pheno yesterday morning as a result of a seizure. The added Pheno will take time to wear off, and in turn, the weakness and instability will be present for a little while to come. I also thought Kbr can cause hind-end weakness, but I'm not certain on that as I'm not familiar with that medication.

Brian

richmauer
Posts: 252
Joined: Fri Dec 07, 2007 5:21 am
Location: Morristown, NJ

Re: Need Help

Post by richmauer » Tue Feb 08, 2011 5:51 am

Does he wear a flea collar?

The meds definitely effect the hind leg weakness. It happens to almost every dog we read about on the forums. By some strange coincidence, Peanut had very bad weakness and we gave her some arthritis formula chews, called Synovi. It is inexpensive and available at Amazon.

http://www.amazon.com/Synovi-Small-Bite ... 10&sr=8-11

It worked. May be worth a shot, but I also think it will self-repair in time anyway.
Btw, any dog with arthritis should use this product. Check it out.
Precious Peanut in doggie heaven 6/25/10 - 10 years old
English Cocker female 10 y/o "Sundae"
Shiatzu Male 10 y/o "Casey"

rougehs1
Posts: 8
Joined: Mon Feb 07, 2011 10:15 am

Re: Need Help

Post by rougehs1 » Tue Feb 08, 2011 1:17 pm

I can't see the affects wearing off as it has been months on the dosages. I think we are going to try to lower the Pheno and up the KBR. Not sure if that will work as I believe they both cause the weakness but hopefully the lower dosage on 1 of the pills will help in that matter. The problem is, she still has seizures. It's not like we can just start lowering drugs because then who knows what will happen. We are feeling very discouraged with the whole thing and are not seeing any light at the end of the tunnel.

richmauer
Posts: 252
Joined: Fri Dec 07, 2007 5:21 am
Location: Morristown, NJ

Re: Need Help

Post by richmauer » Tue Feb 08, 2011 3:58 pm

It is very frustrating, but hang in there. Once they adjust to the meds, she should be ok.
Here is an interesting article which touches on the hind leg weakness. It suggests the Kbr causes it, but doesn't suggest the Pb does. I would be very careful about lowering the dosage. Keep us posted. One question: are her legs weak all the time or only after seizure?
Precious Peanut in doggie heaven 6/25/10 - 10 years old
English Cocker female 10 y/o "Sundae"
Shiatzu Male 10 y/o "Casey"

Mandypop
Posts: 238
Joined: Wed Oct 25, 2006 9:29 am
Location: London, UK

Re: Need Help

Post by Mandypop » Wed Feb 09, 2011 5:14 am

Hello

Sorry you're having such a rough time at present. My dog is on both pheno and KBr. She was started on pheno and we did have some weakness until she adjusted to medication. Unfortunately her seizures started up after a couple of years and we had to intriduce KBr. We had dreadful hind end weakness once we introduced the KBr (she was fine on pheno and even when this was increased). It was only after we reduced KBr (about 10 months into treatment) that her hind end weakness improved massively. So, in our experience, it was the KBr which caused hind end weakness.

Good luck and hope things improve.
Poppy - 9 year old whippet/greyhound (20 kg)

First seizure- 17th Oct 2006
Last seizure - 17th Nov 2009

90mg Pb twice daily
320mg KBr daily

rougehs1
Posts: 8
Joined: Mon Feb 07, 2011 10:15 am

Re: Need Help

Post by rougehs1 » Wed Feb 09, 2011 10:20 am

Thanks for all the replies. Her legs are weak all the time and not only after seizures. You mention an article aboutthe hind weakness but don't have the link posted.

The weakness started to get real bad after we added the KBR but the issue is it seems like it is the drug that has "helped" a bit with the seizures so we can't remove it for that reason. When she was on Pheno alone, it didn't help at all with seizures no matter how high the dosage was.

We now currently have her on 1 1/2 60 mg tablets of pheno twice a day and are looking to drop it to 1 tablet twice a day. She was on as high as 3 tabs twice a day and it didn't help and her liver levels got to high.

She is also on a total of 1500 mg of KBR ( 750 mg twice a day) and are looking to up that to a total of 2000 mg if we drop the Pheno. We added the KBR about 3 months ago.

She is a 6 yr old German Shepard weighing about 80 punds (36 KG).

Post Reply