Any one using Zonisamide (Zonegran) with success?

Questions about the influence of diet and metabolism on seizures.

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googles
Posts: 15
Joined: Sat Feb 16, 2008 1:32 pm
Location: Long Island NY

Any one using Zonisamide (Zonegran) with success?

Post by googles » Wed Feb 20, 2008 7:04 pm

I have a large Tibetan Mastiff that had a total of 6 short seizures. He is 27 months old. The last 3 where about 3 weeks apart. I been doing a lot of research and I didn�t like the Phenobarbital and Potassium Bromide because of the side effects and figured I should try a safer drug before putting him on that stuff. Plus the Phenobarbital I would have to worry about liver damage since he is young and will be on it possibility for a long time. From what I read about Zonisamide there is very few side effects and they use it with humans. So that is the drug I put him on and he seems to be doing good so far. He is the same dog with the same playful personality. Zonisamide is more expensive but I found the private pharmacies where hundreds of dollars cheaper and if you search it makes a big difference in price. He has not had a seizure in almost 4 weeks now so I hope it stays that way but only time will tell. Does anyone know of Zonisamide and used it with success? I have done research on it but there not much info with dogs throughout the internet using it.

adajadesmom
Posts: 104
Joined: Wed Nov 21, 2007 12:28 pm

Post by adajadesmom » Thu Feb 21, 2008 8:17 am

I know I've seen some here that are using it. You may try a search using the word "zonisamide" and should be able to find out about it that way.

Glad to hear it seems to be working for you!

googles
Posts: 15
Joined: Sat Feb 16, 2008 1:32 pm
Location: Long Island NY

Post by googles » Thu Feb 21, 2008 9:30 am

yes i have tried that too but not much on dogs. there unfortunately very little info on it.

skrpio
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Joined: Sun Sep 25, 2005 5:34 pm
Location: Auckland , New Zealand

Post by skrpio » Thu Feb 21, 2008 1:52 pm

PB and KBr get a worse rep than what they deserve. If bloods are done regularly there is usually no problem. dogs have been known to stay on PB for more than 8 years and eventually leave due to old age.
Check out DR Jean Dodds for info on pB. She was the one that told me PB does not deserve the repuataion it gets and is much safer than a dog continually seizing.
Jane
In loving memory of my special KiKi Bean
Seizure free forever now
Nov 25th 2002 - Nov 1st 2006
Dogue De Bordeaux

bajaluna
Posts: 20
Joined: Tue Jan 29, 2008 9:55 pm
Location: Kansas

Post by bajaluna » Wed Mar 12, 2008 7:57 am

Shamus is on PB,Kbr and Zonisamide we just started the zonisamide and no seizures yet

richmauer
Posts: 252
Joined: Fri Dec 07, 2007 5:21 am
Location: Morristown, NJ

Post by richmauer » Wed Mar 12, 2008 5:55 pm

Do you know what you are paying for the zonisamide and what dosage????
Precious Peanut in doggie heaven 6/25/10 - 10 years old
English Cocker female 10 y/o "Sundae"
Shiatzu Male 10 y/o "Casey"

googles
Posts: 15
Joined: Sat Feb 16, 2008 1:32 pm
Location: Long Island NY

Post by googles » Thu Mar 13, 2008 11:56 am

richmauer wrote:Do you know what you are paying for the zonisamide and what dosage????
I am paying 135 dollars for a months supply of Zonisamide and he is taking 500mg a day. If you shop around you can get very different prices. duke has not had a seizure since he been on Zonisamide and its the only drug he is taking. his last seizure was jan 26, 08. so i hope things stay well. I am curious what other people are paying as well and where is a good reliable place to purchase it online. also he has no signs of any side effects from this drug. he is the same playful dog. he has no weight gains or any kind of side effect. its as if he is not on any drug.
Tibetan Mastiff 2 y/o 250mg AM - 250mg PM total 500mg of Zonisamide.

Now he is 6 years old. 600mg AM - 600mg PM total 1200mg of Zonisamide. When he turned 6 he started having frequent seizures so that is why they up his meds. I hope this helps him.

bajaluna
Posts: 20
Joined: Tue Jan 29, 2008 9:55 pm
Location: Kansas

Post by bajaluna » Fri Mar 14, 2008 7:18 am

I am paying 48 dollars for 100 pills thru my local grocery store and he is on 200 mg per day

Merlinsmom
Posts: 28
Joined: Thu Feb 21, 2008 8:41 am

Post by Merlinsmom » Fri Mar 14, 2008 7:56 am

skrpio wrote:PB and KBr get a worse rep than what they deserve. If bloods are done regularly there is usually no problem. dogs have been known to stay on PB for more than 8 years and eventually leave due to old age.
Check out DR Jean Dodds for info on pB. She was the one that told me PB does not deserve the repuataion it gets and is much safer than a dog continually seizing.

Merlin needs something else and I don't want to add KBr because it more than increases the thirst and hunger that he already suffers from with Pb. I want to add Zonisamide as I've heard a lot of good things on it, and for people it is used for partial-onset seizures, which Merlin has. He's going to the vet tonight and I'm going to ask for a Rx for Zonisamide.
Bobbie
Merlin, 10 yr old Pembroke Welsh corgi, seizures since September 07
Jack, 3 year old Pembroke Welsh corgi, seizures since Dec. 06

ilovemylovey
Posts: 36
Joined: Sat Dec 09, 2006 2:15 pm

zonisamide

Post by ilovemylovey » Fri Apr 25, 2008 6:12 pm

how is Merlin on it. I just stARTED MY DOG ON IT TODAY!
TINA
tina and Lovey
75lb lab mut
2 years old
Started PB 1/07
6 pills 384mgs daily
seizures weekly 7-10 apart

Merlinsmom
Posts: 28
Joined: Thu Feb 21, 2008 8:41 am

Post by Merlinsmom » Sat Apr 26, 2008 7:37 am

Merlin is doing pretty well. We added 100 mg twice a day of Zonisamide to 45 mg twice a day of Pb. He went 24 days without a seizure and only had one when I tried to lower the Pb to 30 mg. He started Zonisamide March 15 and since then has had only one seizure.

Started Jack on 25mg BID then upped it to 50, but he was still having seizures so he is now on 100 (no Pb) so we'll see if that helps. I just upped it to 100 on Monday so it hasn't been long enough to tell. Jack seems to have more of a reaction to it as he gets sleepier. They both weigh around 30 lbs.

I'm not finding any really cheap prices, though, we are paying about 60 cents a pill for 100 mg. Costco was $1 a pill so we are ordering online.

Bobbie
Bobbie
Merlin, 10 yr old Pembroke Welsh corgi, seizures since September 07
Jack, 3 year old Pembroke Welsh corgi, seizures since Dec. 06

Merlinsmom
Posts: 28
Joined: Thu Feb 21, 2008 8:41 am

Post by Merlinsmom » Mon Apr 28, 2008 6:05 am

Well, after a week on 100 mg Zonisamide Jack had another seizure, so I think he's switching over to Phenobarbital.

Bobbie
Bobbie
Merlin, 10 yr old Pembroke Welsh corgi, seizures since September 07
Jack, 3 year old Pembroke Welsh corgi, seizures since Dec. 06

skrpio
Posts: 1143
Joined: Sun Sep 25, 2005 5:34 pm
Location: Auckland , New Zealand

Post by skrpio » Mon Apr 28, 2008 1:10 pm

The one problem with PB is that it is really hard to lower the doseage with out having problems.
Jane
In loving memory of my special KiKi Bean
Seizure free forever now
Nov 25th 2002 - Nov 1st 2006
Dogue De Bordeaux

beachcouple
Posts: 5
Joined: Wed Apr 20, 2011 11:19 am

Re: Any one using Zonisamide (Zonegran) with success?

Post by beachcouple » Wed Apr 27, 2011 12:20 pm

We love Zonisamide (ZNS)!

Originally started with 32mg Pb. 2 years later, added 275mg KBr.

Liver enzymes started rising, so added ZNS to begin reducing Pb.

ZNS loading was similar to Pb with weakness and wobbly gate. But all went away in a couple of weeks.

The wonderful side-effect we saw was his mood. Rocky became really happy and started playing like a puppy again. I hope this is a common side-effect since it is heartwarming to see our baby so happy.

ZNS also greatly changed the severity of the seizures. We still averaged one every 5 weeks but sometimes, it was hard to tell that it was actually a seizure. Still a disappointing experience but much less physical.

These are our experiences and you have to realize that your experience may be different. Hopefully better but not necessarily.
Rhonda & Brian
Rocky, Havanese born 1/11/2002
1st seizure: 11/24/2004

Potassium Bromide 275mg daily
50mg Zonisamide BID (was 100mg)
Levetiracetam (Keppra) 250mg TID

Discontinued: PB 11/17/2011 after 7 years

Carolyn
Posts: 440
Joined: Thu Feb 16, 2006 12:08 pm
Location: Long Island, NY

Re: Any one using Zonisamide (Zonegran) with success?

Post by Carolyn » Fri Apr 29, 2011 1:12 pm

Check the prices using Med Saver card http://www.medsavercard.com/ Costco seems to have the best prices. A friend of mine uses Walgreens and between Walgreens plan & the med saver card his savings on meds have been substantial.
Carolyn
Kiya 11yr Shiloh Shepherd
PB 60mg am 90mg pm, 1teas kbr 1200mg, turmeric paste
1000mg milkthistle bid
First seizure 11/27/05
Last seizure 5/21/15

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