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Any one using Zonisamide (Zonegran) with success?

Posted: Wed Feb 20, 2008 7:04 pm
by googles
I have a large Tibetan Mastiff that had a total of 6 short seizures. He is 27 months old. The last 3 where about 3 weeks apart. I been doing a lot of research and I didn�t like the Phenobarbital and Potassium Bromide because of the side effects and figured I should try a safer drug before putting him on that stuff. Plus the Phenobarbital I would have to worry about liver damage since he is young and will be on it possibility for a long time. From what I read about Zonisamide there is very few side effects and they use it with humans. So that is the drug I put him on and he seems to be doing good so far. He is the same dog with the same playful personality. Zonisamide is more expensive but I found the private pharmacies where hundreds of dollars cheaper and if you search it makes a big difference in price. He has not had a seizure in almost 4 weeks now so I hope it stays that way but only time will tell. Does anyone know of Zonisamide and used it with success? I have done research on it but there not much info with dogs throughout the internet using it.

Posted: Thu Feb 21, 2008 8:17 am
by adajadesmom
I know I've seen some here that are using it. You may try a search using the word "zonisamide" and should be able to find out about it that way.

Glad to hear it seems to be working for you!

Posted: Thu Feb 21, 2008 9:30 am
by googles
yes i have tried that too but not much on dogs. there unfortunately very little info on it.

Posted: Thu Feb 21, 2008 1:52 pm
by skrpio
PB and KBr get a worse rep than what they deserve. If bloods are done regularly there is usually no problem. dogs have been known to stay on PB for more than 8 years and eventually leave due to old age.
Check out DR Jean Dodds for info on pB. She was the one that told me PB does not deserve the repuataion it gets and is much safer than a dog continually seizing.

Posted: Wed Mar 12, 2008 7:57 am
by bajaluna
Shamus is on PB,Kbr and Zonisamide we just started the zonisamide and no seizures yet

Posted: Wed Mar 12, 2008 5:55 pm
by richmauer
Do you know what you are paying for the zonisamide and what dosage????

Posted: Thu Mar 13, 2008 11:56 am
by googles
richmauer wrote:Do you know what you are paying for the zonisamide and what dosage????
I am paying 135 dollars for a months supply of Zonisamide and he is taking 500mg a day. If you shop around you can get very different prices. duke has not had a seizure since he been on Zonisamide and its the only drug he is taking. his last seizure was jan 26, 08. so i hope things stay well. I am curious what other people are paying as well and where is a good reliable place to purchase it online. also he has no signs of any side effects from this drug. he is the same playful dog. he has no weight gains or any kind of side effect. its as if he is not on any drug.

Posted: Fri Mar 14, 2008 7:18 am
by bajaluna
I am paying 48 dollars for 100 pills thru my local grocery store and he is on 200 mg per day

Posted: Fri Mar 14, 2008 7:56 am
by Merlinsmom
skrpio wrote:PB and KBr get a worse rep than what they deserve. If bloods are done regularly there is usually no problem. dogs have been known to stay on PB for more than 8 years and eventually leave due to old age.
Check out DR Jean Dodds for info on pB. She was the one that told me PB does not deserve the repuataion it gets and is much safer than a dog continually seizing.

Merlin needs something else and I don't want to add KBr because it more than increases the thirst and hunger that he already suffers from with Pb. I want to add Zonisamide as I've heard a lot of good things on it, and for people it is used for partial-onset seizures, which Merlin has. He's going to the vet tonight and I'm going to ask for a Rx for Zonisamide.

zonisamide

Posted: Fri Apr 25, 2008 6:12 pm
by ilovemylovey
how is Merlin on it. I just stARTED MY DOG ON IT TODAY!
TINA

Posted: Sat Apr 26, 2008 7:37 am
by Merlinsmom
Merlin is doing pretty well. We added 100 mg twice a day of Zonisamide to 45 mg twice a day of Pb. He went 24 days without a seizure and only had one when I tried to lower the Pb to 30 mg. He started Zonisamide March 15 and since then has had only one seizure.

Started Jack on 25mg BID then upped it to 50, but he was still having seizures so he is now on 100 (no Pb) so we'll see if that helps. I just upped it to 100 on Monday so it hasn't been long enough to tell. Jack seems to have more of a reaction to it as he gets sleepier. They both weigh around 30 lbs.

I'm not finding any really cheap prices, though, we are paying about 60 cents a pill for 100 mg. Costco was $1 a pill so we are ordering online.

Bobbie

Posted: Mon Apr 28, 2008 6:05 am
by Merlinsmom
Well, after a week on 100 mg Zonisamide Jack had another seizure, so I think he's switching over to Phenobarbital.

Bobbie

Posted: Mon Apr 28, 2008 1:10 pm
by skrpio
The one problem with PB is that it is really hard to lower the doseage with out having problems.

Re: Any one using Zonisamide (Zonegran) with success?

Posted: Wed Apr 27, 2011 12:20 pm
by beachcouple
We love Zonisamide (ZNS)!

Originally started with 32mg Pb. 2 years later, added 275mg KBr.

Liver enzymes started rising, so added ZNS to begin reducing Pb.

ZNS loading was similar to Pb with weakness and wobbly gate. But all went away in a couple of weeks.

The wonderful side-effect we saw was his mood. Rocky became really happy and started playing like a puppy again. I hope this is a common side-effect since it is heartwarming to see our baby so happy.

ZNS also greatly changed the severity of the seizures. We still averaged one every 5 weeks but sometimes, it was hard to tell that it was actually a seizure. Still a disappointing experience but much less physical.

These are our experiences and you have to realize that your experience may be different. Hopefully better but not necessarily.

Re: Any one using Zonisamide (Zonegran) with success?

Posted: Fri Apr 29, 2011 1:12 pm
by Carolyn
Check the prices using Med Saver card http://www.medsavercard.com/ Costco seems to have the best prices. A friend of mine uses Walgreens and between Walgreens plan & the med saver card his savings on meds have been substantial.